Objective: To develop a reproducible immortalized human chondrocyte culture model for studying the regulation of chondrocyte functions relevant to arthritic diseases in adult humans.

Methods Immortalized human chondrocytes were developed for studying responses to cytokines and prostaglandins.

Over-proliferation of human chondrocytes may contributes to OA pathological process.

Interpretation: The biosynthetic activity of human chondrocytes from osteoarthritic joints can be enhanced using selected compression regimes.

By radio-ligand binding experiments we have shown the existence of similar receptors on the surface of human chondrocytes.

This study dissected dedifferentiation mechanism of in vitro cultured human chondrocytes by microarray analysis of gene expression changes.

Therefore, this study investigated the potential of three different coculture systems, combining human respiratory epithelial cells and human chondrocytes.

With this purpose in mind, human chondrocytes were isolated and cultured using different culture procedures: monolayer, suspension and agar gel.

No such study is available for human chondrocytes although young and old bovine and equine cartilage have been recently profiled.

Our objective is to investigate the effect of I-BET151 on a surgical mouse model of osteoarthritis (OA) and human chondrocytes.